The Sophistication of Simplicity . . . Optimizing Emergency Dosing

Simplicity: the ultimate sophistication.

Efficient movement underpins all great sporting performances. When performed by an expert, complex movements can appear effortless, almost simple; as Leonardo Da Vinci stated, “simplicity is the ultimate sophistication”. Dynamic control of movement is also central to safe sporting function and is dependent on the sophisticated integration of a range of factors including environment, nature of t...

Optimizing dosing of oncology drugs.

The purpose of this article is to acknowledge the challenges in optimizing the dosing of oncology drugs and to propose potential approaches to address these challenges in order to optimize effectiveness, minimize toxicity, and promote adherence in patients. These approaches could provide better opportunities to understand the sources of variability in drug exposure and clinical outcomes during ...

Simplicity is the Ultimate Sophistication: The Future of Mobile Payments - White Paper | Oracle

The Sophistication of Simplicity: Ventricular Function and Oximetry Predict Survival in Eisenmenger Syndrome.

In 1897, Victor Eisenmenger described a patient with cyanotic congenital heart disease and pulmonary hypertension who died at the age of 32. Although >100 years have passed since that initial report, the prognosis of patients with Eisenmenger syndrome has changed relatively little: Eisenmenger syndrome remains incurable, and patients have a high symptom burden and markedly diminished life expec...

Optimizing levodopa dosing routines for Parkinson’s disease

This thesis in the field of microdata analysis aims to introduce dose optimizing algorithms for the pharmacological management of Parkinson’s disease (PD). PD is a neurodegenerative disease that mostly affects the motor functions of the patients and it is characterized as a movement disorder. The core symptoms of PD are: bradykinesia, postural instability, rigidity, and tremor. There is no cure...